As a result, the lollipop chart (Figure 6A) shows that patients in the high-risk group are positively correlated with tumor-infiltrating immune cells (such as B cell memory, cancer-related fibroblasts, macrophages M0, macrophages M1, and T cell CD4+ memory) more activated T cell follicular helper cells and T cell regulators (Tregs), and they are negatively correlated with endothelial cells, macrophages M2, mast cell activation and neutrophils by spearman correlation analysis. The gene discussed is CD4; the disease is cancer.