The humoral factor TotAexhibited the strongest (over 4-fold) downregulation among all proteinsin response to lipidome unsaturation and has been shown to respondto various types of environmental stresses.28 Smg5 is an essential nonsense-mediated mRNA decay factor that wasfound in an obesity screen to regulate TAG levels specifically inmuscle cells.29,30 Lastly, the two predicted plasmamembrane metallopeptidases angiotensin-converting enzymes Ance-4 andNeprilysin 6 were both downregulated in M2-flies, albeit Neprilysin6 was not significantly changed in M3-flies.31,32. The gene discussed is SMG5; the disease is obesity due to melanocortin 4 receptor deficiency.