In the tumor beds of AMDs(i.v.)+light‐treated mice, IL‐1β, IL‐18, and HMGB‐1 were significantly increased, while the cytokines in PBS‐treated and AMDs(i.v.)‐alone treated mice were low, indicating that the tumor‐specific PMR induced local inflammation and the inflammation‐inducing ability was both AMDs and light‐dependent (Figure 6E). This evidence concerns the gene HMGB1 and neoplasm.