In the network, the nodes with more edges might play essential roles in the pharmacological processes, and 12 nodes (edge ≥5) were determined as the main targets of CFF-1 on PCa for further analysis, including NCOA2, RXRA, ESR1, NCOA1, PPARG, IL1B, TNF, IKBKB, NR3C1, IL4, IL6 and PRKCA (Figure 2C). Here, ESR1 is linked to posterior cortical atrophy.