Using various bioinformatics analysis tools, Wang et al. identified seven novel central genes (MME, ALB, CXCL12, CDH1, PROM1, ICAM1, and PTPRC) that may play key roles in the tumorigenesis of human clear cell renal cell carcinoma [38] and Wang et al. demonstrated that a set of five subtype-specific gene markers (CLUL1, CNGB1, ROM1, LRRC39, and RDH12) have the ability to predict retinoblastoma progression with excellent accuracy [39]. This evidence concerns the gene PROM1 and clear cell renal carcinoma.