In MOLT4 cells, an acute lymphoblastic leukemia line, pomalidomide induced significant downregulation of the previously identified neosubstrates IKZF1 (9) and ZFP91 (9, 31), while PT-179 did not significantly downregulate any detected proteins (no downregulation ≥ 2-fold at p ≤ 0.0001; fig. This evidence concerns the gene IKZF1 and acute lymphoblastic leukemia.