However, B- and T-cell infiltration is dispensable for the inflammatory phenotype because transplant arteriosclerosis persists in Bmal1-deficient aortic grafts transplanted into recipients deficient in the adaptive immunity recombination-activating gene (RAG-1).112 These data demonstrate a remarkable and apparently intrinsic vascular function of circadian clocks to condition transplant arteriosclerosis. This evidence concerns the gene BMAL1 and arteriosclerosis.