NR1D1 and myocardial infarction: Furthermore, neutrophil numbers and levels of Il1b, Tnf, Cxcl1, and Cxcl2 were elevated in Nr1d1cKO MI hearts.134 Conversely, cardiac-specific REV-ERBα expression by intramyocardial injection of an AAV (adenoviral vector) encoding Nr1d1 (AAV-Nr1d1) under a cardiomyocyte-specific cTnT (cardiac troponin-T) promoter or REV-ERBα activation by intraperitoneal injection of the agonist SR9009 both alleviated MI damage, regardless of shift work, in both mice and sheep.