Furthermore, neutrophil numbers and levels of Il1b, Tnf, Cxcl1, and Cxcl2 were elevated in Nr1d1cKO MI hearts.134 Conversely, cardiac-specific REV-ERBα expression by intramyocardial injection of an AAV (adenoviral vector) encoding Nr1d1 (AAV-Nr1d1) under a cardiomyocyte-specific cTnT (cardiac troponin-T) promoter or REV-ERBα activation by intraperitoneal injection of the agonist SR9009 both alleviated MI damage, regardless of shift work, in both mice and sheep. This evidence concerns the gene IL1B and myocardial infarction.