The merit of the inducible Bmal1 deletion model is that developmental functions of BMAL1 are not affected so that mice retain normal rhythmic locomotor activities before the tamoxifen treatment.115 Thus, in the constitutive Bmal1 deletion atherosclerosis model, any alterations caused by Bmal1 deletion during development remain unassessed. This evidence concerns the gene BMAL1 and atherosclerosis.