Viruses have evolved numerous strategies to evade the MHC-I antigen presentation pathway, including disruption of MHC-I machinery by suppression of transcription [35, 36, 78, 79, 80], such as the suppression of NLRC5 function by the ORF6 protein of SARS-CoV-2 [41], highlighting the importance of CD8+ T cells in the elimination of virus-infected cells and control of virus infection. Here, NLRC5 is linked to viral infectious disease.