DDIT3 and familial pancreatic carcinoma: Endoplasmic reticulum (ER) stress (Figure4A) is an essential biological process in carcinogenesis, neurodegeneration, and tumorigenesis.[38] C/EBP‐homologous protein (CHOP, 19 kDa) is known as a characteristic marker and a molecular chaperone of ER stress, which regulates translation and apoptosis.[39, 40] Here, we explored CHOP expression heterogeneities in HPDE pancreatic cells (normal cells) and three types of pancreatic cancer cells, including BxPC‐3, Panc1, and SW1990.