MDH2 reversibly converts malate to oxaloacetate, and FH mediates the reversible hydration and dehydration of fumarate to malate.[41] Strategies for exploiting metabolic pathways to treat cancer are being actively investigated.[42, 43, 44] We measured the expression of CHOP, MDH2 and FH in four pancreatic cell subtypes. The gene discussed is MDH2; the disease is cancer.