Loss of NCOA3 protected against high‐fat diet (HFD)‐induced hepatic steatosis.[47] The knockout mice are lean and resistant to obesity upon NCOA3 knockout.[48] Despite these harmful functions on cancer and liver diseases, loss of NCOA3 exhibited decreased growth and development, impaired neurologic, cardiac, and skeletal muscle performance.[49] Considering the conflicting role of NCOA3 on different diseases, side effects have to be taken into account when investigating the prospective therapies targeted to NCOA3. This evidence concerns the gene NCOA3 and liver disorder.