For example, activated Fyn augments oxidative stress, inflammation, endoplasmic reticulum stress, and autophagy dysfunction, resulting in the progression of acute kidney disease (AKI).[30] Fyn which was upregulated in the DKD kidney promoted oxidative stress and impaired renal function.[31] Fyn controls a group of genes that are associated with autophagy. Here, FYN is linked to acute kidney injury.