NPHS1 and glomerulosclerosis: We observed that Cre+/NCOA3fl/fl mice at 12 months old showed elevated albuminuria (Figure S3G, Supporting Information), podocyte deficiency (Figure S3H,I, Supporting Information), glomerulosclerosis (Figure S3J,K, Supporting Information), and podocyte damage as manifested by podocyte foot process broadening, glomerular basement membrane (GBM) thickening, and podocyte process disappearance, and loss of Nephrin (Figure S3I–O, Supporting Information).