NCOA3 and obesity due to melanocortin 4 receptor deficiency: Loss of NCOA3 protected against high‐fat diet (HFD)‐induced hepatic steatosis.[47] The knockout mice are lean and resistant to obesity upon NCOA3 knockout.[48] Despite these harmful functions on cancer and liver diseases, loss of NCOA3 exhibited decreased growth and development, impaired neurologic, cardiac, and skeletal muscle performance.[49] Considering the conflicting role of NCOA3 on different diseases, side effects have to be taken into account when investigating the prospective therapies targeted to NCOA3.