CD44 and ovarian serous adenocarcinoma: ALOX5AP predicts poor prognosis by enhancing M2 macrophage polarization and immunosuppression in the serous ovarian cancer microenvironment,[41] whereas ligation of CD44 triggers the lytic function of cytotoxic T cells and enhances natural killer cell activity.[42] Taken together, these results demonstrate that tumor‐infiltrating cells exhibit distant functions in PCa.