GSK3B and cancer: Interestingly, patient PIGR‐enriched extracellular vesicles drive cancer stemness, tumorigenesis, and metastasis by activating PDK1/Akt/GSK3β/β‐catenin signaling cascades in hepatocellular carcinoma,[6] while MMP7 is closely related to the EMT process, promoting invasion and migration of cancer cells.[7] The other subset, termed “hillock cell,” has a transcriptomic profile very close to club cell but uniquely expresses KRT5 and KRT13.