Using scRNA sequencing, flow cytometry, and immunofluorescence staining, we identified effector T cells in PCa with extensively enhanced CXCR6 expression, a critical receptor that receives signals for cytotoxic T cells survival in the tumor microenvironment.[35] The number of CD8+CXCR6+T subsets is markedly reduced in patients with malignant PCa. This evidence concerns the gene CXCR6 and posterior cortical atrophy.