ATAC‐Seq results revealed that with PCa progression, transcriptional activation of AR target genes, such as KLK2, KLK3, and FKBP5, changed remarkably and correlated with the AR transcriptional program (Figure S3A–C, Supporting Information), whereas patients with CRPC had more accessible chromatin at the KLK11 and AMACR locus (Figure 2I,J). Here, KLK11 is linked to posterior cortical atrophy.