Besides GZMK+CD8+T cells, age‐modified tissue‐specific macrophages and neutrophils may cause chronic low‐grade inflammation, which is related to macrophage‐mediated immunosuppressive disorders, leading to the development of cancer.[36] We found that IL1B‐NLRP3 macrophages and activated neutrophils were the predominant subtypes of macrophages and neutrophils, respectively, in normal controls. The gene discussed is NLRP3; the disease is cancer.