FOXO3 and breast cancer: We also showed, for the first time, that carbon-coated iron oxidenanoparticles might promote reductive stress (reduced levels of ROS,increased activity of FOXO3a and elevated levels of antioxidant enzymes),which, in turn, results in inflammatory response (the activation ofNFκB and elevated production of IL-6 and IL-8), nucleolar stress(relocation of nucleolar proteins), cytotoxic autophagy (increasedlevels of BECN1 and LC3B), and finally apoptotic cell death in drug-inducedsenescent breast cancer cells (Figure 11).