PRR5L expression was found differential in visceral adipose tissue of obesity patients (Guo et al. 2018) and found to be required for efficient mTORC2-mediated activation of SGK1 (serum/glucocorticoid regulated kinase 1) (Pearce et al. 2011). The gene discussed is SGK1; the disease is obesity due to melanocortin 4 receptor deficiency.