Interestingly, as hypoxia is associated with obesity, angiogenesis marker ANGPT1 (angiopoietin 1) correlates positively with adipocyte size and body mass index-standard deviation score (BMI-SDS), a measure to define childhood obesity (Gaebler et al. 2019). This evidence concerns the gene ANGPT1 and obesity due to melanocortin 4 receptor deficiency.