Transcription factor ZFP536 (zinc finger protein 536) is involved in neurone differentiation (Qin et al. 2009) and was associated with both Attention-Deficit/Hyperactivity Disorder (ADHD) and excessive body weight (Dmitrzak-Weglarz et al. 2021), linking psychological disorders with obesity. Here, ZNF536 is linked to obesity due to melanocortin 4 receptor deficiency.