Among the top targets involved in obesity include Pde6h (phosphodiesterase 6 H, cGMP-specific, cone, gamma) (Sosa-Madrid et al. 2020), Lrp5 (low density lipoprotein receptor-related protein 5) (Guo et al. 2006), potentially lncRNA Gm37985 that is predicted to target Hif3a (hypoxia inducible factor 3, alpha subunit) (Mikec et al. 2022), and circRNA Arf3 (ADP-ribosylation factor 3) (Rashad et al. 2023). The gene discussed is HIF3A; the disease is obesity due to melanocortin 4 receptor deficiency.