INS and obesity due to melanocortin 4 receptor deficiency: Moreover, DMVs were also found within the “obesity” genes located in FOB QTLs: D430041D05Rik and Frmd5 (FERM domain containing 5) in Fob1, the aforementioned Nbas in Fob2, and Mamld1 (mastermind-like domain containing 1) in Fob4. Human AGBL1 was associated with levels of circulating adiponectin, a hormone released from adipose tissue that affects insulin sensitivity and inflammatory patterns, and linked to body mass index, visceral fat, and risk of type 2 diabetes mellitus (Hasegawa et al. 2022).