GALNT2 and obesity due to melanocortin 4 receptor deficiency: However, according to the Ensembl database Galnt2l shares 98.69% similarity with Galnt2. Loss of function of GALNT2 lowers high-density lipoproteins in different species (Khetarpal et al. 2016) and is associated with metabolic diseases, including obesity (Antonucci et al. 2022).