For example, microglial CX3CR1 (C-X3-C motif chemokine ligand 1) signalling determine obesity susceptibility in mice (Dorfman et al. 2017) and its deficiency induces inflammation and insulin resistance in adipose tissue (Nagashimada et al. 2021). The gene discussed is CX3CR1; the disease is obesity due to melanocortin 4 receptor deficiency.