SIRT6 and lung cancer: Research has found that overexpression of SIRT6 can significantly inhibit the epithelial–mesenchymal transformation of TGF-β1-induced human lung cancer cell line A549, while overexpression of SIRT6 can negatively regulate the transformation of TGF-β1-induced human fetal lung fibroblasts (HFL1) into myofibroblasts [24].