Cytochrome P450 is an important enzyme in the cellular metabolism and detoxification of drugs and interferes with the metabolism of vitamin E. Adverse effects of vitamin E supplementation have been related to vitamin E-induced activity of P450 enzymes, which in turn enhances the degradation efficiency of drugs used to treat cardiovascular diseases, cancer, metabolic diseases, and other diseases. This evidence concerns the gene CYP2B6 and cardiovascular disorder.