The extent of neuronalcell death in PD patients has been positively correlated with theproportion of activated caspase-3-positive neurons.78 Furthermore, both fibrillar and monomeric forms of α-Synhave been reported to induce complete NLRP3 inflammasome activation,leading to caspase-1 activation and IL-1β production.79 In our study, substantial escalations in bothCaspase-1 and Caspase-3 activities were observed in SH-SY5Y cellsoverexpressing α-Syn and cocultured with CAE. The gene discussed is IL1B; the disease is Parkinson disease.