FGF2 and Papule: Other authors reported that bFGF can enhance angiogenesis in the oral mucosa and accelerate wound healing.35 A significant beneficial influence of topical use of rb-bFGF gel has been found in patients with facial dermatitis.16 The application of rb-bFGF has been demonstrated to reduce erythema, desquamation, papules, and dryness; it is particularly useful in treating rosacea granuloma lesions and in preventing late scar formation.15 These findings suggest a positive treatment effect of rb-bFGF gel in oral-cavity-related diseases.