NFKB1 and Alzheimer disease: Therefore, the dysregulation in the antioxidation, can result in the accumulation of intracellular oxidative stress and trigger the nuclear factor kappa B (NFκB)‐axis, leading to neurodegenerative phenotype polarization.[4, 25] Correspondingly, the level of intracellular ROS was significantly elevated in iMG under AD CM compared to under Con CM (Figure3a,b).