Theyact as tumor promoters via their interaction with PKC and RasGRP,and Braun et al. showed the colocalization and co-migration of receptorsand ligands in real-time analysis;43 theimages of phorbol–BODIPY 18 are shown in Figure 6B. A similar behaviorof RasGRP was reported later. The gene discussed is RASGRP1; the disease is neoplasm.