It is well known that SIRT1 deacetylates p53 to suppress apoptosis.[3] Aspirin has been reported to induce apoptosis in multiple types of cancer cells by inhibiting cyclooxygenase[29] or triggering the release of cytochrome c.[30] To determine whether aspirin‐mediated acetylation of SIRT1 contributes to aspirin‐induced apoptosis, we performed multiple cell‐based assays. Here, TP53 is linked to cancer.