Ye and colleagues conducted IHC staining on adenocarcinoma, squamous cell carcinoma, and various types of pulmonary NENs, including lung typical carcinoid (TC), SCLC, and LCNEC, revealing that the expression of human achaete-scute homolog 1 (hASH1), a regulator of neuroendocrine cells growth, was higher in LCNEC (72.7%) and SCLC (79.2%). The gene discussed is ASCL1; the disease is large cell neuroendocrine carcinoma.