Bari et al. (24) performed RNA sequencing and IHC staining, revealing significant differential expression of caudal type homeobox 2 (CDX2), Villin 1 (VIL1), and brain-specific angiogenesis inhibitor 3 (BAI3) between the cohorts of LCNEC (n = 71) and SCLC (n = 76). Here, ADGRB3 is linked to large cell neuroendocrine carcinoma.