Our meta-analysis revealed the lack of association of <i>CYP2R1</i> (rs10741657), <i>CYP27B1</i> (rs3782130), <i>CYP27B1</i> (rs10877012), <i>CYP24A1</i> (rs6068816), <i>CYP24A1</i> (rs4809960), <i>CYP3A5</i> (rs776746), <i>GC</i> (rs7041), <i>GC</i> (rs4588), and <i>VDR</i> (ApaI: rs7975232) with lung cancer. This evidence concerns the gene CYP3A5 and lung cancer.