A study using tau-PET [18F]AV1451 found an association between poorer CDR-SB scores and higher SUVR in ROIs corresponding to Braak stages I-IV in the MCI group.36 Among Alzheimer’s disease individuals, impairment on the CDR-SB correlated with higher SUVR in regions belonging to Braak stages III-VI.36 Nonetheless, no specific analyses were performed with the functional domains of the CDR-SB.36 These results, however, reinforce the correspondence between CDR-SB scores and PET-based Braak stages in the Alzheimer’s disease continuum. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.