On the other hand, the skin in atopic dermatitis (AD) lesions is hyperinnervated with increased CGRP-positive nerve fibres.37 AD patients experience skin pain resembling neuropathic pain, which can be found in CIDP and GBS patients.38 CGRP is a molecule activated by TRPV1 signalling pathways. The gene discussed is CALCA; the disease is Alzheimer disease.