As a result, in the respective patient subgroups of age >65 years, viral etiology, ALBI grade 1, AFP>1000 ng/mL, PIVKA-II>1000 mAU/mL, ECOG 0, Child-Pugh 5A, largest intrahepatic tumor >5 cm, multiple intrahepatic tumors, or PVI, AB had significant benefits in OS (Supplementary Table 1). The gene discussed is AFP; the disease is neoplasm.