It was recognized that these different cognitive presentations were associated with different distributions of tau pathology in the brain and different patterns of atrophy (Kanne et al., 1998; Galton et al., 2000), with greater involvement of the cortex and relative sparing of the hippocampus compared to amnestic AD patients (Galton et al., 2000). The gene discussed is MAPT; the disease is Alzheimer disease.