MAPT and Alzheimer disease: Most studies in the 1990’s focused on characterizing this amnestic-predominant AD with neuroimaging studies highlighting atrophy of the hippocampus (Seab et al., 1988; Jack et al., 1992) and whole brain (Fox et al., 1996), and neuropathological findings showing that tau pathology spreads from the transentorhinal region to the hippocampus and then the lateral temporal and cortical regions (Braak and Braak, 1991).