TARDBP and Alzheimer disease: This protein is one of the major disease proteins in frontotemporal lobar degeneration (Neumann et al., 2006), but abnormal TDP-43 is also observed in many patients with AD pathology (Amador-Ortiz et al., 2007; Josephs et al., 2008; Uryu et al., 2008; Arai et al., 2009; Davidson et al., 2011).