The role of Reelin in inflammation was recently reviewed (Alexander et al., 2023); however, the various disorders marked by both low Reelin expression and elevated markers of inflammation, such as major depression, schizophrenia, and Alzheimer’s disease, were not considered (Fatemi et al., 2000; Miller et al., 2009; Herring et al., 2012; Muller et al., 2015; Novoa et al., 2022). The gene discussed is RELN; the disease is early-onset autosomal dominant Alzheimer disease.