RELN and major depressive disorder: Although the mechanisms through which Reelin regulates neuronal function to alleviate depression-like behavior in chronically stressed rats is not fully elucidated, regulating synaptic plasticity is one key mechanism through which Reelin treatment reverses stress-induced depression-like behavior, as AMPA receptor blockade prevented the antidepressant-like effects of Reelin treatment in rodents exposed to chronic stress (Brymer et al., 2020).