In the gastric cancer context, the intravenous anesthetic propofol was shown to downregulate lncRNA metastasis-associated lung adenocarcinoma transcript- 1 (MALAT-1) and inhibit ATG5 to suppress autophagy and induce apoptosis, thereby enhancing the chemosensitivity of chemotherapy-resistant gastric cancer cells to cisplatin (Zhang et al., 2020). This evidence concerns the gene ATG5 and gastric cancer.