BECN1 and neoplasm: For example, in a human osteosarcoma experiment, propofol was reported to promote autophagy by upregulating LC3II/I and Beclin-1 protein expression and downregulating the expression of p62 protein via AMPK/FOXO1 signaling pathway, thus inhibiting the proliferation, migration and invasion of tumor cells (Dai et al., 2022).