TP53 and rheumatoid arthritis: The most distinctive feature of FLS in RA, apoptosis resistance, has altered mitochondrial pathways related to apoptosis and can resist receptor-mediated apoptosis at multiple levels, including dysfunction of Bcl2 family proteins, dysregulation of NF-κB signaling, p53 mutations, and low expression of p53 upregulated apoptosis regulator (58).