The majority of incoming NK_T cells, B_Plasma cells, Myeloid cells, and pDCs signalings were characterized by mode 2, driven by pathways such as APP and ANNEXIN (Figure 5D).We found that CD99 can be secreted by almost all types of cells in cervical cancer, and its main target cells (receptors) were tumor epithelial cell subgroups, Fibroblasts and pDCs, among which C3 PLP2+ Tumor EPCs subgroups were most significantly expressed (Figure 5E). This evidence concerns the gene APP and cervical cancer.