In order to verify the independence of risk factors, a gene-cell clinical prediction model was constructed, and multi-factor Cox regression was carried out by combining age, race, T stage, N stage and M stage clinicopathological factors with high PLP2+ Tumor EPCs score group and low PLP2+ Tumor EPCs score group, with a p value of 0.001, indicating that PLP2+Tumor EPCs Score could be independent risk factor (Figure 7J). The gene discussed is PLP2; the disease is neoplasm.