In state1, state2 and state3, the proportion of C0 TMPRSS2+ Tumor EPCs subgroup was the highest, while in state4, the proportion of C1 ANKRD36C+ Tumor EPCs subgroup was the highest, and in state5, the proportion of C3 PLP2+ Tumor EPCs subgroup was the highest, and C4 MKI67+ Tumor EPCs subgroup only existed in state5. Here, TMPRSS2 is linked to neoplasm.