APP and neoplasm: For example, this output showed that the majority of outgoing tumor epithelial cell signaling was characterized by mode 1, which represented multiple pathways, including but not limited to APP, CD99, CDH, ANNEXIN, etc. All output NK_T cells, B_Plasma cells, Myeloid cells, pDCs signalings were characterized by mode 2, which represented pathways such as CD22, CD45, ICAM, CESC L and TNF.