A genome-wide analysis of 57 HIV lymphomas found that genes associated with fragile sites such as Fragile Histidine Triad (FHIT; FRA3B), WW domain-containing oxidoreductase (WWOX; FRA16D), Deleted in Colon Cancer (DCC; FRA18B), and Parkinson Protein 2 (PARK2; FRA6E), are frequently inactivated by mesenchymal deletions in HIV-NHL, and that the prevalence of FHIT alterations is significantly higher in HIV-DLBCL (231). This evidence concerns the gene WWOX and non-Hodgkin lymphoma.