PRSS3 and diffuse large B-cell lymphoma: In a recent whole-exome sequencing of EBV+DLBCL, it was shown that a heterogeneous mutational landscape is associated with DNA double-strand break-homologous recombination repair failure, and genes found to have a high number and frequency of mutations include serine protease 3 (PRSS3), MUC3A and MUC16 (77).