CD4 and central nervous system cancer: The infiltration of CD3+ (259), CD4+ (260), CD8+ (260, 261) T lymphocytes, Tregs (262), monocyte-derived macrophages (263), neutrophils (260), overall CD45+ immune cells, including macrophages, dendritic cells, and T cells (264) was reduced in IDH-mutant gliomas compared with IDH-wild type gliomas.