HMGB1 and diabetic kidney disease: We further found that serum and urine HMGB1 levels were significantly correlated with clinical indicators related to DKD (Table 2, Figure 3A), and the diagnostic efficacy of serum HMGB1 for the occurrence of DKD was better than that of corrected urine HMGB1 (AUC=0.892 v.s. AUC=0.792) (Figure 3B).