The core genes ATG5, RB1CC1, and PARK2 were verified in vivo analysis: The expression levels of ATG5, RB1CC1, and PARK2 in CCL4-induced HF mouse tissues were significantly higher than those in the control group, implicating these genes in the development of HF and validating the results of the bioinformatics analysis. Here, RB1CC1 is linked to hydrops fetalis.