LEP and breast cancer: This reciprocal communication fosters a conducive microenvironment for promoting BC development while concurrently inducing partial phenotypic and functional alterations in adipocytes 13, including 1)lipolysis-induced release of free fatty acids (FFAs) results in reduced volume; 2)enhanced secretion function promotes the mobilization of leptin, adiponectin, IL-6, TNF-α, and other adipokines and pro-inflammatory cytokines; 3)increased interaction between adipocytes and tumor cells regarding lipid metabolism has been observed.