Activation of the PI3K-AKT-mTOR pathway promotes cell migration through downstream SREBP1 up-regulation of SCD1 expression, mediates increased monounsaturated fatty acid (MUFA) synthesis (increased MUFA/ polyunsaturated fatty acids (PUFA) ratio), and protects BC cells from ROS-induced ferroptosis 77, 78. The gene discussed is SREBF1; the disease is breast cancer.