Previously, we found that CDK12 knockout in TECs caused urine concentration defects due to slow Slc12a1 gene transcriptional elongation dynamics and observed that CDK12 regulated DDR in AKI.18,30 However, it is unclear whether CDK12 knockdown can aggravate kidney injury through transcriptional elongation of genes involved in the DDR. Here, CDK12 is linked to acute kidney injury.