To further elucidate the transcriptional effect of CDK12 knockdown on genes in these terms, we performed a long-read sequencing platform-single-molecule real-time sequencing (SMRT) in cisplatin-induced AKI murine model treated with and without CDK12 knockdown, to identify the formation of novel transcripts involved in DNA damage and apoptosis genes. Here, CDK12 is linked to acute kidney injury.