Tubular epithelial cells (TECs) are the nidus of injury during AKI.14,15 CDK12 is mainly expressed in the nucleus of TEC in renal tissue.16 Convincing evidence has shown that CDK12 is positively correlated with renal function in patients with chronic kidney disease.17 Therefore, we speculated that CDK12 downregulation was involved in the progression of kidney injury. Here, CDK12 is linked to acute kidney injury.