CDK12 and acute kidney injury: In fact, the CDK12 activity is regulated by factors such as cell cycle proteins, post-translational modifications, and transcription factors.38 Previous studies have shown that cell cycle arrest and acetylation and lactylation modifications occur after injury in several models of AKI.39, 40 Clearly, these data showed that CDK12 knockdown in tubular cells could induce cellular injury through DNA damage and subsequently cause apoptosis and inhibition of proliferation.