RPS6KB1 and obesity due to melanocortin 4 receptor deficiency: The serine/arginine-rich protein kinase 2 (SRPK2), identified as a key regulator of stress granule (SG) formation in obesity-associated pancreatic ductal adenocarcinoma, modulates SG assembly through the hyperactivation of the IGF1/PI3K/mTOR1/S6K1 pathway.