In a study conducted by Lu et al., it was elucidated that core regulatory circuit components, namely homeobox B8 (HOXB8) and fos-like antigen 1 (FOSL1), residing proximal to the SE locus in osteosarcoma, exhibit the ability to form dense and dynamically phase-separated droplets in vitro and liquid-like puncta within cell nuclei. The gene discussed is FOSL1; the disease is osteosarcoma.