Regardless of whether pharmacological inhibition or knockout of Hspb1 exacerbated AP, pancreatic duct administration of AAV8 (adeno-associated virus 8)-Hspb1 significantly alleviated pancreatic damage, neutrophil and macrophage infiltration, and remote damage to the lung and intestine in the two SAP models. This evidence concerns the gene HSPB1 and alkaline phosphatase measurement.