TFEB and renal fibrosis: We found that the UUO-induced renal fibrosis decreased TFEB proteins and its downstream ATP6V0C-mediated lysosomal biogenesis, resulting in insufficient autophagy and further tubular cell G2/M arrest and ECM deposition, and revealed that TFEB effectively restored the disruption of autophagosome-lysosomal fusion and disorder in autophagy flux in an ATP6V0C-dependent manner through bridging with SNAREs.