TFEB and renal fibrosis: In conclusion, our study emphasized for the first time that impaired TFEB-mediated autophagosome-lysosome fusion disorder, tubular cell G2/M arrest and renal fibrosis appear to be sequentially linked, and modulation of DNA methylation-mediated TFEB expression may potentially serve as a promising therapeutic approach to prevent the advancement of UUO-induced renal fibrosis.