TNF and systemic lupus erythematosus: Additionally, Zhao et al. detected the effect of hucMSC-exos on B cells selected from PBMC of SLE patients, showing that hucMSC-exos promoted B cell apoptosis, prevented B cell overactivation, and reduced IL-16, IL-10, and TNF-α expression of B cells via transferring miR-155 and activating ERK pathway 62.