Atherosclerosis is a chronic inflammatorydisease of the arteriesdue to plaque development.104 Interestingly,high furin levels are detected within human atherosclerotic plaques,including in the carotid artery, aorta, and femoral artery.105 Consistently, a GWAS revealed that FURIN rs17514846 strongly correlates with CAD risk in humans(Table 2).96 Macrophages from individuals carrying the A/Agenotype for rs17514846 (the CAD risk allele) have higher FURIN expression than those carrying the C/C genotype. Here, FURIN is linked to coronary artery disorder.