In CV medicine, furin and its substrates (Table 1) have been demonstratedto play importantphysiological and pathological roles, including in hypertension, diabetesmellitus, dyslipidemia, atherosclerosis, atherosclerotic cardiovasculardiseases (ASCVDs) mainly ischemic stroke and myocardial infarction(MI), and heart failure. This evidence concerns the gene FURIN and heart failure.