In patients with MI, plasma BNP increases up to 60-fold within24 h after the infarction, and the levels decrease gradually.147,148 A second peak might be detected approximately 5 days later, whichis reflective of cardiac remodeling.147,148 Similarlyto an increase in furin, an increase in BNP during MI is associatedwith all-cause mortality and major adverse cardiovascular events (MACEs),which is a composite endpoint of all death, any MI, and any revascularization.149,150. The gene discussed is NPPB; the disease is infarction.