Moreover, researchers suggest that hemojuvelin might act asa prognosticmarker of acute ischemic stroke, given that patients with acute ischemicstroke have increased brain and plasma levels of hemojuvelin.135 This protein acts as a dietary iron sensorand hepcidin activator.138 Mice with hemojuvelindeficiency present a smaller infarct area and lower levels of apoptoticproteins, including cleaved caspase-3,135 evidence that again supports the role of iron overload in ischemicstroke. Here, HJV is linked to Tangier disease.