However,BNP levels are increased in the later stages of hypertension,45 suggesting the alteration of furin expressionand/or the compensatory role of other enzymes, such as PCSK6 and corin.47 These enzymes also play an essential role inblood pressure control via the activation of atrial natriuretic peptide(ANP).48−50. Here, NPPB is linked to hypertensive disorder.