Notably, the current evidence suggeststhat soluble PRR also produces pathobiological functions, includingsodium–water retention (via activation of epithelial sodiumchannel [ENaC]), hypertension (via the local renin–angiotensin–aldosteronesystem [RAAS]), and heart failure.53,55 However, thereare inconsistencies between preclinical and human data. Here, ATP6AP2 is linked to Hypertension.