These G allelesare associated with the risk of hypertension.35,37 Consistently, a genome-wide association study (GWAS) has reportedthat the rs4702 A variant of the FURIN gene, whichresults in decreased furin expression, is associated with an increasein systolic blood pressure, diastolic blood pressure, and peripheralvascular resistance.38 This evidence concerns the gene FURIN and hypertensive disorder.