Proteinbiomarkers detectable in blood or other body fluids also include tissue/cell-specificproteins that have enhanced levels in body fluids as compared to normal,e.g., PSA in the blood plasma of prostate cancer patients.19 Proteome characterization in cancer has beenrecently assessed by two initiatives, the Clinical Proteomic TumorAnalysis Consortium111 and the Human ProteinAtlas.112. Here, KLK3 is linked to Familial prostate cancer.