TP53 and cancer: p53 is one of themost frequently mutated genes incancer, in the early phases of lung, skin, esophageal, and other cancers.149−151 p53 aggregates have been identified as prognostic marker in ovariancancer.152 Mutant p53 is viewed as a biomarkerfor breast cancer153 as well as head andneck squamous cell carcinoma,154 and mayhelp improve cancer surgery results.155