The first category comprises progeroid syndromes with gene mutations encoding proteins with important function for nuclear envelope stability and organization such as Hutchinson-Gilford progeria syndrome (HGPS), atypical progeria syndromes (APS), mandibuloacral dysplasia type A and B (MADA, MADB), restrictive dermopathy (RD) and Nestor-Guillermo progeria syndrome (NGPS). The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.