TARDBP and amyotrophic lateral sclerosis: TDP-43 was shown to have multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation (Sephton et al., 2011) and besides ALS tissue can be detected also in patients with chronic traumatic encephalopathy (CTE) associated with rmTBI (de Boer et al., 2020; Murray et al., 2022).