SOD1 and amyotrophic lateral sclerosis: In addition to other problems, including a decrease in the copy number of the mutation in chromosome 21 affecting ALS severity (Bonifacino et al., 2021), a recent study showed minimal disease-related changes in microglia and oligodendrocytes in SOD1 (G93A) mouse cortex during the end-stage of ALS, which contrasts with findings in patients (Filipi et al., 2023).