NF1 and neurofibromatosis type 1: While protocols have been developed to differentiate hiPSCs into osteoblasts, the impact of NF1 loss in osteoblastic differentiation has not yet been investigated (Csobonyeiova, 2017; Diaz-Hernandez et al., 2023); hiPSCs have never been used to model osseous defects found in NF1 patients.