NF1 and scoliosis: Several studies have shown by genotypic analysis a localized loss of heterozygosity of the NF1 gene in pseudarthrosis or scoliosis tissues, suggesting that biallelic inactivation is necessary to develop bone abnormalities (Stevenson et al., 2006; Lee et al., 2012; Paria et al., 2014; Margraf et al., 2019).