Among the non-hematological toxicities, elevated alanine aminotransferase (ALT) levels were the most prevalent at 38.1%, followed by fatigue at 35.7%, hair loss at 33.3%, hand-foot syndrome at 23.8%, peripheral neuropathy at 11.9%, and nausea and vomiting at 7.1% (Supplementary Table S1). This evidence concerns the gene GPT and Hand-foot syndrome.