Amongst the non-hematological toxicities, the most frequent was alanine aminotransferase (ALT) elevation in 38.1%, followed by fatigue in 35.7%, alopecia in 33.3%, hand-foot syndrome in 23.8%, peripheral neuropathy in 11.9% and nausea and vomiting in 7.1%.Grade 3/4 haematological toxicities were predominantly neutropenia (26.2%), with infrequent cases of thrombocytopenia (2.4%). The gene discussed is GPT; the disease is Hand-foot syndrome.