SNHG15 is upregulated in doxorubicin-resistant cell lines, and knockdown of SNHG15 expression inhibits the proliferation and autophagy of osteosarcoma cells; SNHG15 targets miR-381-3p/GDNF family receptor alpha 1 (GFRA1) expression to promote autophagy and enhances the resistance of osteosarcoma cells to doxorubicin (Zhang J. et al., 2020). The gene discussed is SNHG15; the disease is osteosarcoma.