In CML K562 cells, upregulation of opa interacting protein 5 antisense RNA 1 (OIP5-AS1) expression enhances autophagy, while its downregulation suppresses autophagy and enhances sensitivity to imatinib, and OIP5-AS1 promotes autophagy-related imatinib resistance in CML cells through the miR-30e-5p/ATG12 axis (Dai et al., 2021). The gene discussed is OIP5; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.