EGR1 and acute myeloid leukemia: HOXA transcript antisense RNA, myeloid-specific 1 (HOTAIRM1) promotes the proliferation and autophagy of AML cells; nuclear HOTAIRM1 promoted early growth response 1 (EGR1) degradation by serving as a scaffold to facilitate MDM2 (Murine double minute 2)-EGR1 complex formation, while cytoplasmic HOTAIRM1 acted as a sponge for miR-152-3p to increase ULK3 (Unc-51 like kinase 3) expression (Jing et al., 2021).