Pvt1 oncogene (PVT1) is upregulated in gemcitabine-resistant pancreatic cancer cell lines, and PVT1 promotes Pygopus family PHD finger 2 (Pygo2) and ATG14 expression; the PVT1/miR-619-5p/Wnt/β-catenin axis promotes cellular autophagy and attenuates resistance to gemcitabine (Zhou et al., 2020). Here, PYGO2 is linked to familial pancreatic carcinoma.