Of interest, human GBM and IDH (isocitrate dehydrogenase)-wildtype glioma samples, which are known to have a higher activity of mTOR (TCGA), tended to display (p = 0.059) reduced expression of DNMT3A in comparison with “lower-grade gliomas” (Additional file 1: Fig. S3C). This evidence concerns the gene DNMT3A and glioma.