We then examined the specificity of this DNA-demethylating process by mTORC2 for GBM epigenomic profiles: the methylation status of the gene promoters characteristic of this tumor type (MGMT: O6-methylguanine DNA methyltransferase), which are correlated with the genome-wide methylation pattern in GBM [29]. The gene discussed is MGMT; the disease is neoplasm.