In contrast to genetic manipulation, however, pharmacologic inhibition of GRIA1 by Philanthotoxin-7,4 (PhTx-74) did not significantly affect the migration of GBM cells (Fig. 6F), although PhTx-74 significantly changed glutamate dynamics in GBM cells (Fig. 6G), as an indirect evidence to show its GRIA1 inhibitory activity [13], like in Rictor or GRIA1 knockdown studies (Figs. 5E, 6E). The gene discussed is RICTOR; the disease is glioblastoma.