PRKAR1B and Alzheimer disease: Importantly, the Agora database has ranked PRKAR1B with a score of 4.43, which suggests a high relevance between PRKAR1B and AD based on published evidence including a significant reduction in RNA expression in the temporal cortex and a significant reduction in protein expression in the dorsolateral prefrontal cortex ( https://agora.adknowledgeportal.org/genes ).