PRKACA and congenital primary aphakia: Phosphoproteomic analysis of common PRKACA and PRKACB variants associated with CPA’s identified a profound shift in PKA’s phosphorylation profile, with consistent hyperphosphorylation of citron rho-interacting kinase (CIT), the mitochondrial import receptor subunit TOM34, histone H1.2, and histone H1.4 by three activating PRKACA somatic variants [92].