BRIP1 and Fanconi anemia: The 5′–3′ DNA helicaseFANCJ (Fanconi anemiacomplementation group J) is involved in a number of biological activities,including homologous recombination, DNA damage repair, G4 resolution,and maintaining genomic stability.121 Inorder to facilitate effective DNA replication, FANCJ may unfold andremove G4 structures; in contrast, lack of it will halt replicationat G4s and ultimately result in DNA damage.122 It has been demonstrated that S. cerevisiae’s RecQ helicases Sgs1p and BLM preferentially unwind G4s over Hollidayjunctions.